Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response

Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response

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Editorial summary Inhibitors of poly(ADP-ribose) polymerase (PARPi) have entered the clinic for the treatment of patients Bathroom Accessories with cancers that lack homology-directed DNA repair, but drug resistance remains a clinical hurdle.Recent advances in the identification of PARPi resistance mechanisms have yielded a better understanding of DNA end protection and the Wine Openers relevance of endogenous poly(ADP-ribose) glycohydrolase, highlighting new vulnerabilities.